Studies on drug nonequivalence. X. Bioavailability of 6-mercaptopurine polymorphs.

Studies on the Anti-inflammatory Action of 6-mercaptopurine

The mechanism of action of 6-mercaptopurine (6-MP) on an egg albumin-induced inflammatory lesion in the skin has been studied in rabbits treated with 6-MP in a daily dosage of 18 mg/kg. Relative to control animals, significant decreases in the numbers of large lymphocytes and monocytes in the blood were observed in the 6-MP-treated animals by the 9th day of treatment, without significant decrea...

Effect of 6-mercaptopurine on Endotoxin Tolerance.

Single-crystal diffuse scattering studies on polymorphs of molecular crystals. I. The room-temperature polymorphs of the drug benzocaine.

The drug benzocaine (ethyl 4-aminobenzoate), commonly used as a local anaesthetic, is a bimorphic solid at room temperature. Form (I) is monoclinic P2(1)/c, while the metastable form (II) is orthorhombic P2(1)2(1)2(1). Three-dimensional diffuse X-ray scattering data have been collected for the two forms on the 11-ID-B beamline at the Advanced Photon Source (APS). Both forms show strong and high...

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

Protective Effect on the Liver of Albino Rats Treated with 6 - Mercaptopurine Drug

The leukemia is considered to be one of the most frequent tumors in childhood. The first line of its treatment is 6-mercaptopurine (6-MP). There are many recorded cytotoxic effects for 6-mercaptopurine on tissues such as liver, pancreas and bone marrow. Nowadays the needs for administration of cytotoxic drugs are increased as the incidence of malignancies increases. So we have to search for a s...